Evolution of the protein fold
Proteins are the cell's molecular machines that fold into specific three-dimensional structures
Protein folding on the ribosome
Proteins are the cell's molecular machines that fold into three-dimensional structures
Identification and Analysis of Natural Building Blocks for Evolution-Guided Fragment-Based Protein Design
We believe that our results serve as an invaluable resource for structural and evolutionary biologists.
Cotranslational folding of a pentarepeat β-helix protein
We find that the cotranslational folding of a segment corresponding to the first four of the eight β-helix coils
Effects of protein size, thermodynamic stability, and net charge on cotranslational folding on the ribosome
These findings establish important basic facts about cotranslational folding.
Mutational analysis of protein folding inside the ribosome exit tunnel
We show that AP-based force measurements combined with systematic scans
Evolutionary relationship of two ancient protein superfolds
Our findings contribute to an emerging view in which protein superfolds share a common ancestor.
Change in protein-ligand specificity through binding pocket grafting
In this study we focus on the two homologous polyamine-binding proteins, PotF and PotD.
Design of chimeric proteins by combination of subdomain-sized fragments
Here, we describe a general approach to the design of rational protein chimeras.