Misión

In our laboratory we use bioinformatics, biochemistry and molecular biology to study how biological systems evolve in nature. Our proximal purpose is to learn the evolutionary rules behind the form and function of macromolecular factories like the ribosome to ultimately modify them and create our own synthetic versions. At the moment we are in a foundational stage where we study specific aspects of ribosome biology and its associated proteome.
The ribosome is an exquisite macromolecular factory that translates the genes from all cells into proteins. Recent advances in structural biology, biochemical methods and cryo-electron microscopy have allowed us to better understand the role of the ribosome in the regulation of the cellular proteostasis.

Current research shows that proteins can start to fold and become functional while still being synthesised by the ribosome. In our lab we apply state of the art methods of homology detection, algorithms to detect rare codons and folding predictions to uncover the impact of the ribosome in the structure of the proteome. In our experimental strategies we use one of the most successful developments of synthetic biology: a cell free protein expression system. With this system we produce proteins in carefully determined environments without the restrictions that living cells impose; this allows us to precisely control the elements that influence protein folding during translation. We are a mix of young bioinformaticians and experimentalist, this set up provides the perfect blend for successful projects. In our lab we encourage creativity, innovation and critical thinking in a relaxed environment to promote the development of young Mexican bachelor, master and doctoral students.

Vision

Our long term scientific purpose is to create synthetic biological systems to solve the most pressing national problems. From creating chimeric ribosomes for better protein production to the design of biosensors for detecting and controlling disease. Once we have established the foundations of our lab we will switch our focus from basic biology to applied science. For instance, the next year we will start in house the production of our own cell free expression system to provide the scientific community with efficient and cheap synthetic biology options to produce important proteins like vaccines and antivenoms.

We have a strong commitment with the Mexican society therefore we want to be the place where young Mexican students become seasoned scientist who in the future can tackle national problems with a critical mind and innovative ideas. In our lab we work with an infinite mindset, where collaboration is more important than competition, we set an environment where students can be themselves and develop as young scientists. We provide the support and strategy with a leadership that cares for constant development instead of the traditional metrics of success.